OCT Versus Angiography for Culprit Lesion Revascularization in Acute Myocardial Infarction PatiEnts

Recruiting now · Not applicable

Conditions studied: ST Elevation Myocardial Infarction, Myocardial Infarction

In brief

The aim of the study is to compare clinical outcomes between optical coherence tomography-guided versus angiography-guided percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (AMI).

Key facts

Study ID

NCT06227754

Run by

Chonnam National University Hospital

People needed

1500

Starts

2024-03-25

Expected to finish

2031-12-31

Last updated by the study team

2026-05-08

Who can join

Age: 19 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subject must be at least 19 years of age
• Acute ST-segment elevation myocardial infarction (STEMI)
• STEMI: ST-segment elevation ≥0.1 mV in ≥2 contiguous leads or documented newly developed left bundle-branch block1
• Primary percutaneous coronary intervention (PCI) in < 12 h after the onset of symptoms for STEMI patients
• Subject is able to verbally confirm understandings of risks, benefits and treatment alternatives of receiving invasive physiologic evaluation and PCI and he/she or his/her legally authorized representative provides written informed consent prior to any study related procedure.

You may not qualify if…

• Target lesions not amenable for PCI by operators' decision
• Ostial lesions located in left main vessel or right coronary artery (left main body or distal bifurcation lesions can be enrolled by operator's discretion)
• Creatinine clearance ≤30 ml/min/1.73 m2 and not on dialysis (chronic dialysis dependent patients are eligible for enrolment regardless of creatinine clearance)
• Cardiogenic shock (Killip class IV) at presentation
• Intolerance to Aspirin, Clopidogrel, Prasugrel, Ticagrelor, Heparin, or Everolimus
• Known true anaphylaxis to contrast medium (not allergic reaction but anaphylactic shock)
• Pregnancy or breast feeding
• Non-cardiac co-morbid conditions are present with life expectancy <2 year or that may result in protocol non-compliance (per site investigator's medical judgment)
• Unwillingness or inability to comply with the procedures described in this protocol

Where it is running

• Daegu Catholic University Medical Center — Daegu, Daegu, South Korea (enrolling)
• Kyungpook National University Hospital — Daegu, Daegu, South Korea (enrolling)
• Yeungnam University Medical Center — Daegu, Daegu, South Korea (enrolling)
• Chonnam National University — Gwangju, Gwangju, South Korea (enrolling)
• Wonkwang University Hospital — Iksan, Iksan, South Korea (enrolling)
• International St. Mary's Hospital — Incheon, Incheon, South Korea (enrolling)
• Jeju National University Hospital — Jeju City, Jeju-do, South Korea (enrolling)
• Jeonbuk National University Hospital — Jeonju, Jeonju, South Korea (enrolling)
• Gyeongsang National University Hospital — Jinju, Jinju, South Korea (enrolling)
• Kyung Hee University Hospital — Seoul, Seoul, South Korea (enrolling)
• Samsung Medical Center — Seoul, Seoul, South Korea (enrolling)
• Chung-Ang University Hospital — Seoul, Seoul, South Korea (enrolling)
• Ewha Womans University Seoul Hospital — Seoul, Seoul, South Korea (enrolling)
• Ewha Womans University Mokdong Hospital — Seoul, Seoul, South Korea (enrolling)
• Korea University Guro Hospital — Seoul, Seoul, South Korea (enrolling)
• St. Carollo Hospital — Suncheon, Suncheon, South Korea (enrolling)
• Uijeongbu St Mary's Hospital — Uijeongbu-si, Uijeongbu, South Korea (enrolling)
• Ulsan University Hospital — Ulsan, Ulsan, South Korea (enrolling)

Full record on ClinicalTrials.gov

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