Dupixent in Adults With Refractory Post-Burn Pruritus in an Ambulatory Clinic

Recruiting now · Phase 2 · Has a placebo group

Conditions studied: Pruritis

In brief

The goal of this study is to test the efficacy of Dupixent in improving post-burn itching symptoms versus the current standard of care.

Key facts

Study ID

NCT06226610

Run by

Akron Children's Hospital

People needed

46

Starts

2024-11-21

Expected to finish

2026-12-31

Last updated by the study team

2025-09-19

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Persons 18-60 year old with post-burn hypertrophic scars of any size which required grafting or epidermal autografting for an acute burn injury, with continued complaint of pruritus due to inadequate relief from standard of care (medical management by antihistamine and neuroleptic medications) after at least four weeks and are a minimum of four weeks after their last grafting surgery, and who speak English sufficient to participate in the study.

You may not qualify if…

• Currently taking Dupixent for any other diagnosis
• known allergy to Dupixent
• pregnant and or lactating mothers
• anyone treated for pruritus using laser therapy
• currently receiving adequate relief for pruritis under standard of care medical management by antihistamine or neuroleptic medications
• Currently taking steroids
• persons with developmental delays or otherwise unable to complete measures
• prisoners or anyone otherwise unable to give their own consent or who is not their own guardian
• one or more of the following existing disorders: conjunctivitis; any co-existing dermatological condition except burns; any type of cancer; requiring dialysis; chronic Stage 3 or higher kidney disease; biliary disorder; gall bladder disorder; or another renal or hepatic disorder which, in the opinion of study physician, deems this study inappropriate for an eligible individual.
• Persons unable to provide their own consent, including prisoners when their incarcerated status is not itself the focus of study, are routinely excluded from clinical trials at this site
• We further exclude persons with other dermatological conditions (other than burn) , which may have pruritis or pain associated with them and who may be treated with medications other than Dupixent, and whose perceived benefit could confound our results.
• We similarly exclude anyone treated for pruritis by laser therapy as their perceived benefit could confound our results.

Where it is running

• Akron Children's Hospital — Akron, Ohio, United States (enrolling)

Full record on ClinicalTrials.gov

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