Pharmacist-Driven Stress Ulcer Prophylaxis Minimization in the Intensive Care Unit

Completed

Conditions studied: Stress Ulcer

In brief

Pharmacologic stress ulcer prophylaxis is routinely used in the intensive care unit (ICU) to prevent upper gastrointestinal (GI) bleeding in critically ill patients.

Key facts

Study ID: NCT06225167
Run by: Methodist Health System
People needed: 120
Starts: 2023-05-13
Expected to finish: 2023-07-17
Last updated by the study team: 2026-03-23

Who can join

Age: 18 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Patients ≥18 years ICU location status

You may not qualify if…

If patient has one of the following:
Coagulopathy (defined as: platelets < 50,000/µL, international normalized ratio(INR) > 1.5, or partial thromboplastin time > 2 times the control value)
Mechanical ventilation for > 48 hours and on < 50% goal tube feeds
Shock state on vasopressors/inotropes and on < 50% goal tube feeds (or < 50% of diet)
On total parenteral nutrition
Use of acid suppressive therapy prior to admission
Admission with GI bleeding
History of peptic ulcer disease
Surgery on the GI tract or cardiac surgery during the current hospital admission
Pregnancy
H. pylori infection treatment
Hypersecretory disorder (ex: Zollinger-Ellison)
Known erosive esophagitis/gastritis (not heartburn or gastroesophageal reflux disease)
Traumatic brain injury with Glasgow Coma Scale score ≤ 10
Major burn (˃30% body surface area)
Major trauma requiring ICU admission
Spinal cord injury requiring ICU admission
If patient has two or more of the following:
Administration of ˃ 100 mg daily of prednisolone (or equivalent)
Sepsis
Acute renal failure
Acute hepatic failure

Where it is running

Methodist Richardson Medical Center — Richardson, Texas, United States

Full record on ClinicalTrials.gov

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