Myokine Identification Following Acute Exercise
Completed · Not applicable
Conditions studied: Adiposity
In brief
Exercise stimulates a cascade of responses within the human body. For example, exercise results in the release of proteins into the circulation which communicate with cells and organs throughout the body. In fact, recent human research identified more than 600 proteins are released into the blood circulation following short-term exercise, many of which are predicted to come from the skeletal muscle and target the fat tissue. However, identification of these muscle-secreted proteins and their target tissue (i.e. fat tissue) remains extremely challenging. This challenge is because tissue needs to be collected from multiple sites (skeletal muscle and fat) and at multiple timepoints (before and after exercise). This study seeks to address these challenges through the collection of fat and blood both before and after short-term exercise followed by protein detection (of the blood) and gene expression (of the fat tissue).
Key facts
- Study ID
- NCT06223035
- Run by
- Rockefeller University
- People needed
- 12
- Starts
- 2024-04-18
- Expected to finish
- 2024-08-09
- Last updated by the study team
- 2025-03-10
Who can join
Age: 18 and older, up to 45. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- passing the PARQ questionnaire (i.e. answering "NO" to all questions)
- being between the ages of 18-45
- being moderately active (defined as participating in 30 minutes of recreational activity at least once per week for the past 3 months but no more than 3 times per week)
- non-smoking
- free of metabolic or cardiovascular diseases
You may not qualify if…
- unhealed fractures
- thrombophlebitis (blood clots)
- recent surgery of the upper or lower extremities (any surgeries in past 6 months at the ankle or foot, or in the past year at the knee, hip, shoulder or elbow)
- recent uncontrolled bruising
- recent muscle, bone or joint damage which interferes with regular physical activity
- taking part in vigorous physical activity more than 3 times per week
- any prior sensations of chest pain during exercise.
- individuals who are pregnant as determined by an on-site pregnancy test
- individuals who are currently taking exogenous hormones
- individuals who chronically consume NSAIDS or other anti-inflammatory medication (every day for the previous 3 months)
- failing the PARQ questionnaire as indicated by answering "YES" to any of the questions
- Having a BMI >32
- Any medical condition that in the opinion of the investigator will confound interpretation of data for analysis.
Where it is running
- Rockefeller University — New York, New York, United States
Full record on ClinicalTrials.gov
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