Short-term And Longer-term Cognitive Impact Of Neurochecks
Recruiting now · Not applicable
Conditions studied: Intracerebral Hemorrhage
In brief
The proposed research plan seeks to understand the impact of sleep disruption in the Neurological Intensive Care Unit (ICU) on older patients with acute brain injury (ABI). In current practice, the neurocritical care community performs frequent serial neurological examinations ("neurochecks") in an effort to monitor patients for neurological deterioration following brain injury. Many neurocritical patients are older and/or cognitively fragile, and delirium is common. Although ICU delirium is multifaceted, frequent neurochecks may represent a modifiable risk factor if the investigators can better understand the risks and benefits of various neurocheck frequencies. This project will randomize patients with acute spontaneous intracerebral hemorrhage (ICH) to either hourly (Q1) or every-other-hour (Q2) neurochecks and evaluate the impact of neurocheck frequency on delirium. Second, longer-term cognitive outcomes will be investigated in patients with ICH randomized to Q1 versus Q2 neurochecks with the goal of identifying whether hourly neurochecks increase the risk for dementia.
Key facts
- Study ID
- NCT06219889
- Run by
- University of California, San Diego
- People needed
- 120
- Starts
- 2024-07-08
- Expected to finish
- 2029-10-31
- Last updated by the study team
- 2025-09-10
Who can join
Age: 18 and older, up to 100. Sex: any. Healthy volunteers: not accepted.
You may not qualify if…
- Patients with unstable intracranial bleeding
- Patients with known history of intracranial neurological injury
- Pre-existing cognitive impairment (known or highly suspected based on family-provided history, Activities of Daily Living Questionnaire)
- Pre-existing diagnosed sleep disorder
- Comatose or heavily sedated
- Death expected within 30 days or other terminal illness
- ICH score >4 (equivalent to mortality risk >72%)
- Pregnancy
- Incarcerated
- Non-English or non-Spanish speaking
Where it is running
- UC San Diego Health — San Diego, California, United States (enrolling)
Full record on ClinicalTrials.gov
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