Laser Acupuncture for Chronic Migraine

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Chronic Migraine

In brief

A single-blind randomized controlled trial was conducted from October 2024 to May 2025. Chronic migraine patients were randomly assigned in a 1:1 ratio to receive either Laser acupuncture or sham treatment. The co-primary outcomes were changes in monthly migraine days (MMD) and acute headache medications usage days per month from baseline, and Hospital Anxiety and Depression Scale (HADS), and Beck's Depression Inventory(BDI) evaluation. Evaluations were taken at baseline and each follow-up point. After \>6 months follow up as washing out time, the sham group received complementary laser acupuncture treatment and follow up for another 3 months, compared the Headache related parameters (onset, duration, pain scale, current medication for headache, menstrual cycle).

Key facts

Study ID

NCT06219694

Run by

Taichung Veterans General Hospital

People needed

60

Starts

2022-01-01

Expected to finish

2025-12-01

Last updated by the study team

2025-11-20

Who can join

Age: 20 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• patients aged above 20 years old and had CM managed pharmacologically, including preventive and/or acute migraine medications, and in addition, those who had refused preventive agent despite recommendation of the neurologist;
• patients who had unsatisfactory effect of current pharmacological treatments, defined as they self-reported
• patients who had a minimum of one-year history of migraine with or without aura.

You may not qualify if…

• patients who had received another LA therapy or traditional acupuncture at baseline
• migraine onset after the age of 50
• cognitive or psychological impairment interfering with the participant's ability to receive LA protocol and describe symptoms
• patients with missing data at baseline or during the follow-up period.

Where it is running

• Taichung Veterans General Hospital — Taichung, Xitun District, Taiwan (enrolling)

Full record on ClinicalTrials.gov

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