Effect of Honey For CIN II

Recruiting now · Phase 1/Phase 2

Conditions studied: Cervical Intraepithelial Neoplasia-II, High Risk Human Papillomavirus

In brief

The following hypothesis is tested: Medical grade honey in CIN II causes a higher clearance of the hr-HPV virus and an increase in the normalization of CIN II lesions compared to expectant management.

Key facts

Study ID

NCT06219018

Run by

Zuyderland Medisch Centrum

People needed

60

Starts

2024-12-30

Expected to finish

2027-12-01

Last updated by the study team

2025-06-18

Who can join

Age: 18 and older, up to 40. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Women 18-40 years
• Primary CIN II confirmed histologically in the biopsy on colposcopic examination
• Sufficient mastery of the Dutch language

You may not qualify if…

• Simultaneous abnormality in columnar epithelial cells (AIS).
• Hr-HPV negative cytology
• Immunosuppressant use/Autoimmune disease (HIV, CVID)
• History of cervical carcinoma or previous treatment for CIN (LLETZ or imiquimod)
• Pregnancy or the intention to become pregnant during the study period
• Legal incompetence
• Known allergies to honey

Where it is running

• Zuyderland MC — Heerlen, Limburg, Netherlands (enrolling)
• Maastricht University Medical Centre+ — Maastricht, Limburg, Netherlands

Full record on ClinicalTrials.gov

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