Vasopressin for Septic Shock Pragmatic Trial
Completed · Phase 4
Conditions studied: Septic Shock
In brief
Life-threatening low blood pressure due to a serious infection is called "septic shock." Septic shock is treated with vasopressors, medications that raise blood pressure. Sometimes first-line vasopressors are inadequate, prompting addition of a second-line vasopressor called vasopressin. However, the threshold at which to start vasopressin remains unclear. This pragmatic, cluster-randomized, cluster-crossover trial will evaluate two different strategies for septic shock treatment commonly used in current practice, comparing a lower versus a higher threshold for adding vasopressin to first-line vasopressors.
Key facts
- Study ID
- NCT06217562
- Run by
- Intermountain Health Care, Inc.
- People needed
- 3959
- Starts
- 2024-02-01
- Expected to finish
- 2026-06-06
- Last updated by the study team
- 2026-08-03
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age ≥18 years
- Admitted to a study hospital emergency department (ED) or inpatient care unit
- Administration of vasopressor(s) for septic shock
- Exclusion Criteria: None
Where it is running
- Cassia Regional Hospital — Burley, Idaho, United States
- American Fork Hospital — American Fork, Utah, United States
- Cedar City Hospital — Cedar City, Utah, United States
- Layton Hospital — Layton, Utah, United States
- Logan Regional Hospital — Logan, Utah, United States
- Intermountain Medical Center — Murray, Utah, United States
- McKay-Dee Hospital — Ogden, Utah, United States
- Park City Hospital — Park City, Utah, United States
- Utah Valley Hospital — Provo, Utah, United States
- Riverton Hospital — Riverton, Utah, United States
- LDS Hospital — Salt Lake City, Utah, United States
- Alta View Hospital — Sandy City, Utah, United States
- St. George Regional Hospital — St. George, Utah, United States
Full record on ClinicalTrials.gov
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