Magnetic Resonance Imaging Study on Young and Middle-aged Patients With Cervical Spondylotic Pain

Recruiting now

Conditions studied: Neck Pain

In brief

Cervical and shoulder pain in young adults is commonly caused by intervertebral disc degeneration, bulge or herniation. Disc degeneration includes the synthetic and degradative imbalance of myxoid matrix, degeneration of annulus collagen, and decrease of water content in nucleus pulposus. A few patients with cervical degeneration had moderate to severe pain, but there are no obvious abnormalities in the shape and signal of the disc with routine MRI, which may be related to the early discal degeneration. In most cases, the pain could be relieved by non-surgical treatment due to mild decreased proteoglycan and slight abnormality of water diffusion, but these changes cannot be clearly demonstrated by routine MRI. Therefore, it is necessary to rely on sensitive MRI techniques to reflect the abnormal microstructure in the nucleus pulposus and annulus fibrosus, so as to assist the early detection of the main reason in patients with neck and shoulder pain and the evaluation of the efficacy of treatment.

Key facts

Study ID

NCT06217029

Run by

First Affiliated Hospital Xi'an Jiaotong University

People needed

80

Starts

2024-01-06

Expected to finish

2027-12-31

Last updated by the study team

2024-02-26

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Neck and shoulder pain, with or without upper limb pain and numbness;
• Disease duration longer than 2 months
• Visual analogue score (VAS) ≥ 3
• Cervical MRI showing cervical disc degeneration, bulge, protrusion, etc.
• Patients will undergo non-surgical treatment (maxillary occipital traction, massage, etc.)

You may not qualify if…

• Severe trauma and surgery in neck and shoulder region.
• X-ray or CT showing the severe cervical spine hyperplasia, infection (suppurative, tuberculous), neoplasm (various primary and secondary tumors), rheumatic (rheumatoid arthritis, ankylosing spondylitis), and nuclei pulposus calcification.
• Cervical MRI revealed organic lesions such as inflammation of the spinal cord, tumors, syringomyelia, etc.
• Chronic pain in other regions.

Where it is running

• The First Affiliated Hospital of Xi'an Jiaotong University — Xi'an, Shaanxi, China (enrolling)

Full record on ClinicalTrials.gov

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