Effect of Pulsatile Hormone Administration on Insulin Action

Recruiting now · Not applicable

Conditions studied: Insulin Sensitivity

In brief

In humans, insulin is secreted in pulses from the pancreatic beta-cells, and these oscillations help to maintain fasting plasma glucose levels within a narrow normal range. Given the fluctuations in insulin concentrations, oscillations enhance precision of control. The hyperinsulinemic euglycemic clamp test (clamp) involves a continuous infusion of insulin and is the gold standard for measuring insulin sensitivity. In this study, insulin sensitivity measured using the standard clamp will be compared with a clamp in which the same total amount of insulin as the standard clamp is infused every five minutes instead of continuously.

Key facts

Study ID

NCT06216665

Run by

Pennington Biomedical Research Center

People needed

12

Starts

2024-03-04

Expected to finish

2025-12-01

Last updated by the study team

2025-01-16

Who can join

Age: 50 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Completion of the Motivate Study (NCT05649176)

You may not qualify if…

• Non-completion of the end-of-study hyperinsulinemic euglycemic clamp test of the Motivate study

Where it is running

• Pennington Biomedical Research Center — Baton Rouge, Louisiana, United States (enrolling)

Full record on ClinicalTrials.gov

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