Prospective Validation of Adaptive Radiotherapy (ART) in Patients With Head and Neck Tumors

Recruiting now · Not applicable

Conditions studied: Head and Neck Cancer, Adaptive Radiotherapy, Radiation, Optimized Treatment, Protection of Organs at Risk, Dysphagia Reduction

In brief

Adaptive radiotherapy (ART) includes image-guided radiotherapy (IGRT) and also offers further possibilities for plan adaptation. A particularly high benefit can be expected for patients in whom the clinical target volume (CTV) can show a significant change in shape from fraction to fraction due to anatomical deviations. The shape and position constancy of the CTV during the course of the series is examined in this trial. Dosimetric disadvantages of this type have not been reported so far. The aim of this study is to identify patients who benefit from ART at an early stage and to select them for this method, and then to continue to offer ART to this patient group. If a relevant reduction in the minimum planning target volume (PTV) margins with ART compared to IGRT is demonstrated in this study, patients could be treated with ART.

Key facts

Study ID

NCT06214611

Run by

University Hospital, Essen

People needed

50

Starts

2023-11-15

Expected to finish

2027-12-15

Last updated by the study team

2024-09-27

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• ECOG 0-1
• Histopathology confirmation
• Compliance
• Tumor in the head and neck region
• Indication for radiotherapy

You may not qualify if…

• Pregnancy

Where it is running

• Department for Radiotherapy, University Hospital Essen, National Center for Tumor Diseases (NCT) West — Essen, Germany / NRW, Germany (enrolling)

Full record on ClinicalTrials.gov

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