Study Comparing Tarlatamab and Durvalumab Versus Durvalumab Alone in First-Line Extensive-Stage Small-Cell Lung Cancer (ES-SCLC) Following Platinum, Etoposide and Durvalumab
Running, not enrolling · Phase 3
Conditions studied: Extensive-Stage Small-Cell Lung Cancer, Small-Cell Lung Cancer
In brief
The primary objective of this study is to compare the efficacy of tarlatamab plus durvalumab with durvalumab alone on prolonging overall survival (OS).
Key facts
- Study ID
- NCT06211036
- Run by
- Amgen
- People needed
- 563
- Starts
- 2024-06-05
- Expected to finish
- 2028-09-30
- Last updated by the study team
- 2025-12-17
Who can join
Age: 18 and older, up to 99. Sex: any. Healthy volunteers: not accepted.
Where it is running
- University of Southern California — Los Angeles, California, United States
- Yale New Haven Hospital — New Haven, Connecticut, United States
- University Cancer and Blood Center LLC — Athens, Georgia, United States
- Emory University — Atlanta, Georgia, United States
- Northeast Georgia Medical Center — Gainesville, Georgia, United States
- University of Illinois Chicago — Chicago, Illinois, United States
- Franciscan Health Indianapolis — Indianapolis, Indiana, United States
- Our Lady of the Lake Cancer Institute — Baton Rouge, Louisiana, United States
- Dana-Farber Cancer Institute — Boston, Massachusetts, United States
- Cancer and Hematology Centers of Western Michigan — Grand Rapids, Michigan, United States
- Mayo Clinic — Rochester, Minnesota, United States
- Allina Health System dba Allina Health Cancer Institute — Saint Paul, Minnesota, United States
- Oncology Hematology Associates — Springfield, Missouri, United States
- Nebraska Cancer Specialists — Omaha, Nebraska, United States
- Astera Cancer Care — East Brunswick, New Jersey, United States
- Rutgers Cancer Institute of New Jersey — New Brunswick, New Jersey, United States
- Montefiore Medical Center - Bronx — The Bronx, New York, United States
- Duke University — Durham, North Carolina, United States
- Wake Forest University Health Sciences — Winston-Salem, North Carolina, United States
- Oncology Hematology Care Incorporated — Cincinnati, Ohio, United States
- University Hospitals Cleveland Medical Center — Cleveland, Ohio, United States
- The Ohio State University — Columbus, Ohio, United States
- Oncology Associates of Oregon, PC — Eugene, Oregon, United States
- Oregon Health and Science University — Portland, Oregon, United States
- Infirmary Cancer Center — Mobile, Alabama, United States
Full record on ClinicalTrials.gov
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