Staph Intervention for Effective Local Defense

Completed · Phase 4

Conditions studied: Staphylococcus Aureus Infection

In brief

Indigenous persons experience a high burden of Staphylococcus aureus (SA) invasive disease and skin and soft tissue infections. SA carriage on the skin is factor for development of SA infections. The goal of this clinical trial is to evaluate a community-informed approach to reduce carriage of SA. Participants will be assigned to education and household supplies for prevention of SA with and without a biomedical intervention. Researchers will compare SA carriage in the two groups.

Key facts

Study ID

NCT06210594

Run by

Johns Hopkins Bloomberg School of Public Health

People needed

78

Starts

2024-04-01

Expected to finish

2025-11-14

Last updated by the study team

2026-06-12

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Native American adult living on or adjacent to the WMA Tribal lands
• 18 years of age and older
• Lab-confirmed SA carriage at time of enrollment
• Ability to provide written informed consent
• Ability to comply with follow-up activities
• Risk factor for SA-associated infection: Diagnosed with diabetes OR body mass index ≥30 OR documented SSTI or SA infection in the past 3 years

You may not qualify if…

• Immediate family member of study staff
• Allergy to citrus or any ingredient in Nozin, Hibiclens, or mupirocin
• Without a permanent home (e.g., living in a group home, shelter, or is unhoused)
• Use of antibiotics within 30 days prior to the first study visit (time-limited)
• Current SA infection (time-limited)

Where it is running

• Whiteriver Center for Indigenous Health — Whiteriver, Arizona, United States

Full record on ClinicalTrials.gov

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