A Study of 68Ga-PSMA-11 PET Scans in People With Brain Tumors

Running, not enrolling · Early Phase 1

Conditions studied: High-grade Glioma, Brain Metastases, Brain Metastases, Adult

In brief

The purpose of this study is to find out whether 68Ga-PSMA-11 PET/CT is effective in assessing tumor uptake (tumor activity seen in cancerous tissue) in participants with high-grade glioma/HGG or brain metastases.

Key facts

Study ID

NCT06209567

Run by

Memorial Sloan Kettering Cancer Center

People needed

11

Starts

2024-01-05

Expected to finish

2027-01-05

Last updated by the study team

2025-12-03

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Ability to understand and the willingness to sign (or their legally acceptable representative (LAR) must sign) a written informed consent document
• Adults ≥ 18 years old
• Suspicion for or histologically or cytologically confirmed and previously treated HGG or brain metastases from a primary extracranial malignancy
• Lesion size ≥ 1 cm (for the lesion to be biopsied)
• ECOG performance status ≤ 2 (Karnofsky ≥ 60%)
• Planned to undergo biopsy/resection of brain lesion

You may not qualify if…

• Inability to undergo a PET scan (e.g., claustrophobia or noncompatible implant in case PET/MR is performed)
• Pregnant or nursing female. All women of childbearing potential must have a documented negative serum or urine pregnancy test <1 week before study.
• Uncontrolled, intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiacarrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
• Patients with severe allergy to both iodinated and gadolinium contrast.

Where it is running

• Memorial Sloan Kettering Basking Ridge (All Protocol Activities) — Basking Ridge, New Jersey, United States
• Memorial Sloan Kettering Monmouth (All Protocol Activities) — Middletown, New Jersey, United States
• Memorial Sloan Kettering Bergen (All Protocol Activities) — Montvale, New Jersey, United States
• Memorial Sloan Kettering Suffolk-Commack (All Protocol Activities) — Commack, New York, United States
• Memorial Sloan Kettering Westchester (All Protocol Activities) — Harrison, New York, United States
• Memorial Sloan Kettering Cancer Center (All Protocol Activities) — New York, New York, United States
• Memorial Sloan Kettering Nassau (All Protocol Activities) — Uniondale, New York, United States

Full record on ClinicalTrials.gov

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