Tranexamic Acid Use on Pain, Mobility and Bleeding Following Total Hip and Total Knee Arthroplasty

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Postoperative Bleeding

In brief

Tranexamic acid (TXA) is an anti-fibrinolytic agent developed in the 1960s that has been safely used to reduce blood loss, transfusion rates and bleeding-associated mortality in trauma, obstetrics and orthopedic surgery, including hip fracture care and arthroplasty. The efficacy and safety profile of TXA has been extensively studied in numerous clinical trials and observational studies. Its wide range of applications, combined with its favourable risk-benefit ratio, has led to the incorporation of TXA into clinical guidelines and protocols worldwide. This RCT aims to compare the current standard dosing for TXA to additional TXA doses given orally post-operatively for THA and TKA patients. The goal is to compare the following between study groups: visible bleeding on post-operative dressing, mobilization (steps, amount of time moving around), pain (visual analog scale), function (Oxford hip and knee scales) and ROM at four to six weeks.

Key facts

Study ID

NCT06208267

Run by

St. Mary's Research Center, Canada

People needed

210

Starts

2025-08-20

Expected to finish

2027-07-01

Last updated by the study team

2026-04-28

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• ° All adults undergoing primary TKA and THA at St-Mary's Hospital

You may not qualify if…

• Age < 18 years
• Known hypersensitivity or allergy to TXA
• Previous history of thromboembolic disease
• Active malignancy (all current cancers other than local skin cancer)
• Significant renal disease (hematuria, dialysis, kidney transplant)
• History of convulsions
• Known defective colour vision
• Inability or unwillingness to use MyMobility app
• Unable to communicate in French or English

Where it is running

• St. Mary's Hospital Center — Montreal, Quebec, Canada (enrolling)

Full record on ClinicalTrials.gov

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