The Effects of Chiropractic in a Population With High Central Adiposity

Completed · Not applicable

Conditions studied: Abdominal Obesity

In brief

Since 1980, the global prevalence of obesity, commonly defined as a body mass index (BMI) of 30 or higher, has doubled. Importantly, high levels of central adiposity (i.e., abdominal fat) is associated with numerous PNI-related sequelae, including increased levels of psychological distress, cognitive deficits, ANS dysfunction, and immune marker abnormalities. To our knowledge, rigorous investigation of chiropractic's impact on psychoneuroimmunological (PNI)-related outcomes in people with high central adiposity is lacking. Based on limited evidence to date, it is plausible that clinically important PNI-related dysfunctions (e.g., heightened stress levels, executive function impairments, dysautonomia, immune dysregulation) common in this population could be ameliorated via chiropractic care.

Key facts

Study ID

NCT06208163

Run by

Life University

People needed

18

Starts

2024-11-11

Expected to finish

2025-09-04

Last updated by the study team

2026-05-08

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 18-65 years of age
• Body mass index (BMI) at least 30
• Waist circumference at least 35 inches if female or 40 inches if male

You may not qualify if…

• Had chiropractic care within the past 30 days
• Prescribed short-acting benzodiazepines which include midazolam \& triazolam
• If taking prescription medications, other than short-acting benzodiazepines, not on a stable dose for a minimum of 6 weeks with plans to change medications or doses during the study
• Not able to walk unassisted on a treadmill
• Known disorder resulting in syncope/fainting during postural changes (e.g., POTS, orthostatic hypotension)
• Pacemaker or known heart condition that influences the electrical or mechanical function of the heart (e.g., severe heart valve disease)
• Diagnosed with externalizing (e.g., substance use, antisocial disorder) or thought (e.g., schizophrenia, paranoid personality, bipolar) disorder that is uncontrolled or untreated
• Diagnosed with rheumatoid arthritis, osteoporosis, or cervical spine instability
• Hearing impairment (cognitive task uses auditory stimuli)
• Currently pregnant
• Current litigation related to a physical, health-related injury
• Whiplash injury in the past 3 months
• Oral injury, inflammation, or disease that causes the mouth or gums to bleed easily

Where it is running

• Life University — Marietta, Georgia, United States

Full record on ClinicalTrials.gov

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