The Antimicrobial Potential of Diclofenac Sodium as an Intracanal Medicament

Recruiting now · Phase 2/Phase 3

Conditions studied: Endodontic Disease, Pulp Disease, Dental, Intracanal Medication

In brief

The goal of this randomized clinical trial is to evaluate the capability of the material to exert bacterial reduction of diclofenac sodium versus of that calcium hydroxide paste when these materials are used as intracanal medications in permanent molar teeth with chronic apical periodontitis. The main question\[s\] it aims to answer are: • Will the diclofenac sodium (NSAIDs) possess antimicrobial efficacy to be used effectively as an intracanal medicament similar to that of calcium hydroxide in primary endodontic treatment? Participants will be allocated randomly into three equal groups by using computer generated randomization, according to the type of intracanal medication.

Key facts

Study ID

NCT06207253

Run by

British University In Egypt

People needed

48

Starts

2025-11-01

Expected to finish

2025-12-01

Last updated by the study team

2025-05-30

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Patients with teeth diagnosed with apical periodontitis
• Periapical Index (PAI) ≥ 2
• The teeth are restorable

You may not qualify if…

• Teeth with immature roots
• Non restorable teeth
• Medically compromised patients with systemic complication that would alter the treatment.
• Teeth with internal/external root resorption
• Patient with an allergy to diclofenac sodium

Where it is running

• British university in Egypt — Cairo, Egypt (enrolling)

Full record on ClinicalTrials.gov

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