The Effect of Prehospital Combination of Epinephrine, Vasopressin, and Steroid in OHCA
Recruiting now · Not applicable
Conditions studied: Cardiac Arrest, Out-Of-Hospital Cardiac Arrest, Emergency Medical Services
In brief
This project is a randomized controlled clinical research design, The hypothesis P-I-C-O of the study is: For adult patients in the Taipei City and New Taipei City communities who have suffered sudden non-traumatic death and have been resuscitated by advanced paramedics, the intervention group that receives combined drug treatment (epinephrine, vasopressin, methylprednisolone) has a better rate of sustained recovery of spontaneous circulation (ROSC) (primary outcome) and long-term survival status (secondary outcomes) compared to the control group that receives single drug treatment (epinephrine).
Key facts
- Study ID
- NCT06203847
- Run by
- National Taiwan University Hospital
- People needed
- 1344
- Starts
- 2024-07-16
- Expected to finish
- 2026-12-31
- Last updated by the study team
- 2025-11-19
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Adult patients (aged >= 18 )
- Out-of-hospital cardiac arrest in the studied regions
- Treated by paramedics authorized and capable of giving prehospital medication
You may not qualify if…
- OHCA with traumatic etiology
- Obvious signs of death like decapitation, rigor mortis, livor mortis, decomposition, etc.
- DNR (Do Not Resuscitation) or termination of resuscitation requested by the family
- Patients with known or suspected pregnancy
- No vascular access was established before hospital arrival
- ROSC before the administrated medication
- No patient contact (cancelled ambulance call or the patient was transported to the hospital before the arrival of trial-trained paramedics)
- Received epinephrine prior to the arrival of trial-trained paramedics
Where it is running
- National Taiwan University Hospital — Taipei, Taiwan (enrolling)
Full record on ClinicalTrials.gov
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