Monitoring of Patients With Diffuse Gliomas Using Circulating miRNAs
Recruiting now
Conditions studied: Glioma, Malignant
In brief
MicroRNAs are small non-coding RNAs involved in the post-transcriptional regulation of genes and, consequently, of intracellular signalling pathways that govern cellular behaviour (Komatsu et al., 2023). They are widely implicated in oncogenesis, and in particular in mechanisms promoting cell migration, invasion and proliferation (Romano et al., 2021). Several preliminary studies have shown that serum levels of pro-oncogenic microRNAs correlate with tumor rates in gliomas (Jones et al., 2021; Levallet et al., 2022; Morokoff et al., 2020). Morokoff's study showed encouraging but insufficient results on the possibility of using microRNAs to differentiate radionecrosis versus recurrence. These results need to be consolidated prospectively, with homogeneous samples taken from all patients. The aim of this study is to describe the evolution over time of plasma levels of pro-oncogenic microRNAs, after surgery for grade 4 glioma, in order to assess whether they can be used to identify false-positive recurrences on MRI (radionecrosis).
Key facts
- Study ID
- NCT06203496
- Run by
- University Hospital, Caen
- People needed
- 60
- Starts
- 2024-01-01
- Expected to finish
- 2026-12-31
- Last updated by the study team
- 2024-01-12
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Major patient
- Grade 4 diffuse glioma
- Surgery in the neurosurgery department of Caen University Hospital
- Patient affiliated to a social security scheme
- Patient followed at Caen University Hospital
- No opposition from patient
You may not qualify if…
- - Patients who underwent biopsy (lack of material for study, limited interest of monitoring for these patients without surgical excision).
- Patients with grade 1 circumscribed glioma or grade 2 or 3 diffuse glioma.
- Other non-glial histologies, glioneuronal histology
- Minor patients
- Patient not affiliated to a social security scheme
- A minor under guardianship or protection
- Patient opposed to study
Where it is running
- Arthur Leclerc — Caen, France (enrolling)
Full record on ClinicalTrials.gov
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