A Novel Combinatory Approach to Maximize Functional Recovery of Learning and Memory in Multiple Sclerosis

Recruiting now · Not applicable

Conditions studied: Multiple Sclerosis

In brief

The goal of this novel study is to compare the effect of a combined cognitive rehabilitation and exercise approach on new learning and memory (NLM) in persons with multiple sclerosis (pwMS) and mobility disability.

Key facts

Study ID

NCT06197685

Run by

Kessler Foundation

People needed

78

Starts

2024-02-12

Expected to finish

2027-09-30

Last updated by the study team

2026-08-05

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Be within the ages of 18 and 70 years of age
• Speak English as their primary language
• Confirmed MS diagnosis by a neurologist
• Be relapse and steroid-free for at least 30 days
• Mild-to-moderate self-reported mobility disability, based on the Patient Determined Disease Steps scale (PDDS)
• Currently physically inactive, based on the Godin Leisure Time Exercise Questionnaire (GLTEQ)
• Right handedness

You may not qualify if…

• History of neurological disorders besides MS or history of uncontrolled psychiatric disorders (ex: major depression)
• Have contraindications to exercise, based on the Physical Activity Readiness Questionnaire (PAR-Q)
• Currently use medications that may impact cognition (ex: steroids, benzodiazepines)
• Currently pregnant
• Contraindication for MRI (metal or electronic devices in the body that are not considered MRI safe)
• Severe cognitive impairment as measured by the Modified Telephone Interview of Cognitive Status (TICS-M)

Where it is running

• Kessler Foundation — East Hanover, New Jersey, United States (enrolling)

Full record on ClinicalTrials.gov

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