Feasibility Of Objective Measures and Outpatient Washout in Disease Modifying Trials for Parkinson's Disease

Completed

Conditions studied: Parkinson Disease

In brief

This study will evaluate the feasibility of adding objective measures (FDG-PET imaging, wearable biosensors) to a week-long washout protocol in early-stage Parkinson's disease patients. This study is also determining whether the washout can be conducted in the ambulatory setting.

Key facts

Study ID

NCT06192823

Run by

Vanderbilt University Medical Center

People needed

20

Starts

2022-03-22

Expected to finish

2025-02-18

Last updated by the study team

2026-05-08

Who can join

Age: 50 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• *A clinical diagnosis of idiopathic PD. The diagnosis will be based upon the presence of at least two of the three cardinal motor signs of this disorder (akinesia/bradykinesia, rest tremor, and rigidity) with at least one of the signs being rest tremor or bradykinesia.
• Clear and dramatic beneficial response to dopaminergic therapy (defined as demonstrating at least 30% improvement in parkinsonian motor signs based upon the UPDRS-III motor examination subscore, following the administration of their dopaminergic medications during the screening neurological examination)
• *Hoehn and Yahr (H\&Y) stage II when off medication.
• Age between 50 and 75 years.
• Subjects must be on dopaminergic therapy for at least one year prior to the screening visit and less than four years prior to the completion of the washout period.
• Subjects must have a stable response to dopaminergic medication.
• Available for follow-up for the entire duration of the study.
• Subjects receiving antidepressant medication used specifically for the treatment of depression must be on stable doses for at least eight weeks prior to enrolling in the study.
• Subjects must agree to maintain a stable regimen, if deemed medically appropriate by the treating physician, of any psychotropic medications throughout the study.

You may not qualify if…

• *Evidence of an alternative diagnosis or secondary parkinsonism, as suggested by:
• Features unusual early in the clinical course (e.g., prominent postural instability, freezing phenomena, or hallucinations unrelated to medications in the first 3 years after symptom onset)
• Dementia preceding motor symptoms
• Neurologic signs of upper motor neuron or cerebellar involvement
• Significant orthostatic hypotension unrelated to medications
• Unequivocal cortical sensory loss (i.e., graphesthesia, stereognosis with intact primary sensory modalities), clear limb ideomotor apraxia, or progressive aphasia
• Vertical supranuclear gaze palsy, or selective slowing of vertical saccades
• Unequivocal cerebellar abnormalities on examination, such as cerebellar gait, limb ataxia, or cerebellar oculomotor abnormalities (e.g., sustained gaze-evoked nystagmus, macro square wave jerks, hypermetric saccades)
• Documentation of a condition known to produce parkinsonism and plausibly connected to the subject's symptoms (e.g., history of stroke, exposure to toxins, or encephalitis; or neuroleptic use within the past 6 months)
• *The expert evaluating physician, based on the full diagnostic assessment, believes that an alternative syndrome is more likely than PD.
• *Uncontrolled medical condition or clinically significant medical disease that would increase the risk of developing pre- or postoperative complications (e.g., significant cardiac or pulmonary disease, uncontrolled hypertension).
• *Evidence of existing dyskinesias.
• *Diagnosis of probable behavioral variant frontotemporal dementia or primary progressive aphasia.
• *Currently active diagnosis of a major psychiatric disorder
• Previous brain operation or injury.
• Active participation in another clinical trial for the treatment of PD.
• *Any current substance use disorder.
• Any history of recurrent or unprovoked seizures.
• Any prior movement disorder treatments that involved intracranial surgery or device implantation.
• Any active implanted intracranial device (e.g., cochlear implant) or implanted device to treat movement disorders (e.g., duodopa pump) whether turned on or off.
• History of suicide attempt.
• A female who is breastfeeding or of child-bearing potential with a positive urine pregnancy test or not using adequate contraception.
• Inability or unwillingness of subject to give written informed consent.
• *Parkinsonian features restricted to the lower limbs for more than three years.
• *Treatment with a dopamine receptor blocker or a dopamine-depleting agent in a dose and timecourse consistent with drug-induced parkinsonism.

Where it is running

• Vanderbilt University Medical Center — Nashville, Tennessee, United States

Full record on ClinicalTrials.gov

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