Ventilatory Parameters in Acute Neurological Injury
Recruiting now
Conditions studied: Neurologic Decompensation, Acute, Traumatic Brain Injury, Stroke, Subarachnoid Hemorrhage
In brief
The goal of this observational study is to test the association between baseline ventilatory parameters (in particular mechanical power (MP), mechanical power normalized to predicted body weight (MP/PBW) and driving pressure (DP) with the baseline neurological status (assessed through the Glasgow coma score) in adults patients under mechanical ventilation with acute neurological injury secondary to stroke, brain trauma or subarachnoid hemorrhage. The main question\[s\]it aims to answer are: 1. In patients with acute neurological injury under mechanical ventilation, is there a correlation between the acute neurological injury, assessed using the Glasgow scale on admission, and baseline ventilatory parameters? 2. In patients with acute neurological injury under mechanical ventilation, are the baseline ventilatory parameters altered at baseline?
Key facts
- Study ID
- NCT06192342
- Run by
- Ramos Mejía Hospital
- People needed
- 19
- Starts
- 2024-05-01
- Expected to finish
- 2027-05-30
- Last updated by the study team
- 2026-03-30
Who can join
Age: 16 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Acute neurological injury in patients ≥ 16 years of age with requiring mechanical ventilation for neurological causes and without baseline lung injury, defined as: normal chest x-ray and adequate oxygenation; PaO2/FiO2 ≥ 300.Neumovent TS and Neumovent Advance respirators will be used.
You may not qualify if…
- Pneumothorax, or a pleural drainage tube. Hemodynamic instability (mean blood pressure ≤ 65 mmHg) or high doses of inotropes (Norepinephrine > 0.5 gammas/kilo/minute or equivalent).
- PaO2/FiO2 < 80 mmHg. Chronic obstructive pulmonary disease (COPD). Pregnant
Where it is running
- Roberto Santa Cruz — Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina (enrolling)
Full record on ClinicalTrials.gov
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