Effects of Cycling and Virtual Reality on Thinking Speed in Persons With MS (PACE-MS)

Completed · Not applicable

Conditions studied: Multiple Sclerosis

In brief

To compare the effects of cycling exercise with different types of virtual reality on processing/thinking speed in persons with multiple sclerosis (MS).

Key facts

Study ID

NCT06191380

Run by

Kessler Foundation

People needed

23

Starts

2024-02-12

Expected to finish

2025-10-28

Last updated by the study team

2025-10-30

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Speak English as their primary language
• Confirmed MS diagnosis by a neurologist
• Be relapse and steroid-free for at least 30 days
• Mild-to-moderate self-report mobility disability

You may not qualify if…

• History of neurological disorders besides MS or history of uncontrolled psychiatric disorders (ex: major depression)
• Have contraindications to exercise, based on the Physical Activity Readiness Questionnaire (PAR-Q)
• Currently use medications that may impact cognition (ex: steroids, benzodiazepines)
• Currently pregnant
• Severe cognitive impairment as measured by the Modified Telephone Interview of Cognitive Status (TICS-M)
• No indication of age-related mild cognitive impairment or dementia, based on the MOCA-Blind (i.e., MOCA-Blind ≥19).
• High likelihood of motion sickness
• Regular cyclist, defined as cycling for at least 150 minutes/week

Where it is running

• Kessler Foundation — East Hanover, New Jersey, United States

Full record on ClinicalTrials.gov

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