Exhaled Breath Condensate Analysis in Mechanically Ventilated Patients

Recruiting now

Conditions studied: Acute Respiratory Failure, Critical Illness

In brief

Mechanically ventilated intensive care patients will be sampled for a small amount of exhaled breath condensate from the ventilator circuit and for venous blood. Proteomic analysis of the exhaled breath condensate will be performed using mass spectrometry and in the blood sample, corresponding changes in the DNA, RNA, proteins, and metabolites will be studied. Resulting profiles will be correlated with routinely monitored parameters in order to identify patterns corresponding to various pathologies in order to enable their early detection.

Key facts

Study ID

NCT06189924

Run by

The Institute of Molecular and Translational Medicine, Czech Republic

People needed

200

Starts

2026-03-01

Expected to finish

2029-12-31

Last updated by the study team

2026-06-25

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Intensive care setting Mechanical ventilation Ventilator/ventilator circuit technically suitable for sampling of exhaled breath condensate

You may not qualify if…

• Mechanical ventilation challenging to the extent that the insertion of the sampling kit into the ventilator circuit would substantially increase the risk for respiratory deterioration

Where it is running

• Institute of Molecular and Translational Medicine, Palacky University — Olomouc, Czechia (enrolling)
• University Hospital Olomouc — Olomouc, Czechia (enrolling)

Full record on ClinicalTrials.gov

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