Electrosurgical Modes for Endoscopic Submucosal Dissection in Peroral Endoscopic Esophageal Myotomy

Recruiting now · Phase 3

Conditions studied: Achalasia, Achalasia Cardia

In brief

Peroral endoscopic esophagel myotomy (POEM) is a third space endoscopy technique that depends on creating a submucosal tunnel to expose the esophageal muscle and eventually perform an esophageal myotomy. Submucosal dissection can be performed using numerous electrosurgical modes. Spray coagulation has been anecdotally favored by many endoscopists due to its high coagulation power and assumed safety. Recently, Precisect mode has been developed, it has theoretical advantages of very minimal tissue penetration and minimal to no charring effect. In this trial, the investigators compare the efficacy and safety of both electrosurgical modes in POEM procedures.

Key facts

Study ID

NCT06189859

Run by

Cairo University

People needed

52

Starts

2024-03-16

Expected to finish

2025-08-01

Last updated by the study team

2025-05-13

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients undergoing POEM procedure for any esophageal motility disorder
• Esophageal motility disorder confirmed by high-resolution manometry and gastroscopy

You may not qualify if…

• Esophageal varices
• Esophageal neoplasms
• Non-correctable coagulopathy
• Failure to provide an informed consent

Where it is running

• Cairo University — Cairo, Egypt (enrolling)

Full record on ClinicalTrials.gov

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