Establishment and Evaluation of Prenatal Prevention and Treatment Strategy for NARDS

Recruiting now · Not applicable

Conditions studied: Acute Respiratory Distress Syndrome, Respiratory Distress Syndrome, Acute

In brief

1. A predictive model for NARDS was established based on perinatal risk factors. Multivariate Logistic regression analysis was used to screen the independent prenatal risk factors for NARDS. A Logistic regression model was constructed using the above independent risk factors and quantified in a nomogram to construct a visualization model for prenatal prediction of NARDS. 2. The role of ACS in the prevention and treatment of ARDS in near-term/full-term infants. For neonates with a probability greater than 80% in the prediction model of ARDS, at least one ACS was given before the termination of pregnancy. The GC level of cord blood (taken at birth) and the mRNA levels of α-ENaC, Na-K-atpase and SGK1 in nasal epithelium were measured within 2 hours and 1 day after birth in the ACS intervention group and the control group. The occurrence and severity of pulmonary edema, the occurrence and severity of ARDS, and the mortality rate of NARDS were evaluated by lung ultrasound. The indexes of the two groups were compared horizontally and longitudinally.

Key facts

Study ID
NCT06188195
Run by
The Second Affiliated Hospital of Chongqing Medical University
People needed
500
Starts
2024-02-01
Expected to finish
2025-12-31
Last updated by the study team
2025-06-04

Who can join

Age: any. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

You may not qualify if…

Where it is running

Full record on ClinicalTrials.gov

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