Eosinopenia in Severe COPD Exacerbation

Recruiting now

Conditions studied: Chronic Obstructive Pulmonary Disease

In brief

The goals of this observational study are to identify factors independently associated with admission eosinopenia in patients with a severe exacerbation of chronic obstructive pulmonary disease (COPD) and to determine when blood eosinophil count (BEC) will recover to baseline stable state in patients who are admitted to hospital with a severe exacerbation of COPD and associated eosinopenia. The main aims of the study are to: 1. Identify demographic, physiological and clinical factors independently associated with admission eosinopenia in patients with a severe exacerbation of COPD 2. Assess the time to recovery from eosinopenia to stable BEC following a severe exacerbation of COPD

Key facts

Study ID

NCT06188065

Run by

Northumbria Healthcare NHS Foundation Trust

People needed

200

Starts

2024-01-22

Expected to finish

2026-07-01

Last updated by the study team

2026-04-14

Who can join

Age: 35 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Admitted to hospital with primary clinical diagnosis of exacerbation of COPD*
• Smoking history of at least 10 pack years
• Airflow obstruction: FEV1/FVC ratio < 0.7 confirmed on historic or inpatient spirometry
• Capacity to give informed consent to participate

You may not qualify if…

• Parasitic infection, systemic fungal infection (excluding infection limited to nails or skin), eosinophilic granulomatosis with polyangiitis, hypereosinophilic syndrome or other conditions associated with a high eosinophil count#
• Active malignancy
• Maintenance oral prednisolone or other systemic steroids, anti-interleukin 5 therapy or other medication known to influence eosinophils
• Patients with poor venous access
• Investigator confirmed history of asthma
• Non-COPD related health problems which in the view of the primary investigator may compromise the conduct and completion of the study
• ADDITIONAL CRITERIA FOR THE TIME TO RECOVERY FROM EOSINOPENIA ANALYSIS ONLY
• Inclusion criteria:
• Eosinopenia on admission
• Uneventful recovery*
• Eosinopenia on admission who do not receive a further course of systemic corticosteroids or require emergency hospital admission for an acute illness in the six weeks following admission to hospital with a severe exacerbation of COPD.

Where it is running

• Northumbria Healthcare NHS Foundation Trust — North Shields, United Kingdom (enrolling)

Full record on ClinicalTrials.gov

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