Effects of Two Different Exercise Programs and Diet in Obese Subjects With NAFLD

Recruiting now · Not applicable

Conditions studied: Obesity, NAFLD

In brief

The aim of the study is to estimate the effectiveness of two different exercise programs combined with the Mediterranean diet versus diet alone on inflammatory status in subjects aged 18-65 years with obesity (BMI\>30) and Non-Alcoholic Fatty Liver Disease (NAFLD) (CAP \>248 dB/m).

Key facts

Study ID

NCT06186869

Run by

Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis

People needed

90

Starts

2023-10-02

Expected to finish

2026-12-23

Last updated by the study team

2026-03-27

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• BMI ≥ 30 kg/m2 or an abdominal circumference (waist) > 94 cm in men and > 80 cm in women (IDF criteria for the definition of abdominal obesity) with or without the characteristics that characterise metabolic syndrome
• Age range 18-65 years, both sexes
• Diagnosis of hepatic steatosis, formulated on the basis of recognised criteria (fibroscan (CAP (controlled attenuation parameter) > 238 dB/m)).

You may not qualify if…

• Normal and underweight subjects
• Presence of any pathology that may influence the presence of steatosis apart from pathologies that are inclusion criteria, neurological and psychiatric pathologies, gastrointestinal, oncological and cardiovascular diseases
• Pregnancy or breastfeeding
• Subjects with osteoarticular pathologies that may prevent regular exercise
• Inability to quantify the degree of NAFLD by Fibroscan
• Person not in possession of a medical certificate of fitness for non-competitive physical activity.

Where it is running

• IRCCS De Bellis — Castellana Grotte, Bari, Italy (enrolling)

Full record on ClinicalTrials.gov

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