Effects of High-intensity Exercise Training on Physical Fitness, Cognition, Language in Post-stroke Aphasia

Completed · Not applicable

Conditions studied: Aphasia, Acquired, Aphasia, Aphasia, Fluent, Aphasia Non Fluent

In brief

The goal of this clinical trial is to establish the feasibility and fidelity of a high-intensity exercise program for individuals with post-stroke aphasia. The main questions it aims to answer are: * Is it feasible for stroke survivors with aphasia to participate in a long in-person physical exercise program? * Does participation in a physical exercise program lead to physical fitness, cognitive, language and/or psychological changes? Participants can take part in two different physical exercise interventions: * Low intensity intervention (control intervention); * High-intensity physical exercise intervention (target intervention).

Key facts

Study ID

NCT06185023

Run by

University of California, Berkeley

People needed

12

Starts

2023-12-11

Expected to finish

2026-01-15

Last updated by the study team

2026-02-17

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• aphasia following single or multiple ischemic or hemorrhagic stroke;
• at least 6 months from the last stroke;
• proficient in English before the stroke;
• at least 8 years of education;
• between the ages of 18 and 80;
• independent with ambulation without a device (single-point cane accepted);
• medically stable with no contraindications to participate in regular physical exercise as determined by the patient's own primary care provider or other treating provider.

You may not qualify if…

• prior history of dementia, neurologic illness (other than stroke), or substance abuse;
• significant visual or hearing disabilities (e.g., neglect, uncorrected visual or hearing loss) that interfere with testing;
• per self-report uncontrolled cardiorespiratory and/or metabolic disorders incompatible with exercise.

Where it is running

• University of California Berkeley — Berkeley, California, United States
• California State University East Bay — Hayward, California, United States
• University of San Francisco — San Francisco, California, United States
• University of California San Francisco — San Francisco, California, United States

Full record on ClinicalTrials.gov

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