Lithium Versus Lamotrigine in Bipolar Disorder, Type II

Recruiting now · Phase 4

Conditions studied: Bipolar II Disorder

In brief

The investigators want in a 6-month randomized controlled trial (RCT) to compare effects of lithium versus lamotrigine on mood stabilization and other critical patient outcomes in patients with BDII.

Key facts

Study ID

NCT06184581

Run by

University Hospital Bispebjerg and Frederiksberg

People needed

200

Starts

2024-05-08

Expected to finish

2027-12-01

Last updated by the study team

2026-03-20

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Bipolar disorder, type II with diagnosis confirmed by SCAN interview
• Age 18-70 years
• Habile (i.e., able to give informed consent)

You may not qualify if…

• Past non-response or intolerance to lamotrigine or lithium with > 6 weeks treatment at an adequate dosage
• Currently taking mood stabilizers at enrollment in CADIC
• Severe chronic kidney disease
• Severe cardiac insufficiency
• Brugadas syndrome
• Severe hypothyroidism despite treatment
• Women who are pregnant, breastfeeding or planning pregnancy in near future.

Where it is running

• Psychiatric Center Copenhagen — Copenhagen, Denmark (enrolling)

Full record on ClinicalTrials.gov

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