Serologic Response to Pneumococcal Vaccination Among Esophageal Cancer Patients With High Grade Lymphopenia After Chemoradiation

Recruiting now

Conditions studied: Pneumococcal Vaccine, Esophageal Cancer, Lymphopenia, Chemoradiation

In brief

To learn how radiation treatment may affect your responses to vaccines against pneumonia.

Key facts

Study ID

NCT06181656

Run by

M.D. Anderson Cancer Center

People needed

80

Starts

2024-02-05

Expected to finish

2027-07-04

Last updated by the study team

2026-05-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Group 1A
• a. Patients currently receiving, planning to receive, or recently completed chemoradiation for esophageal cancer with protons.
• Group 1B
• a. Patients currently receiving, planning to receive, or recently completed chemoradiation for esophageal cancer with intensity-modulated radiation therapy (IMRT)
• Group 2A
• a. Patients currently receiving, planning to receive, or recently completed definitive proton therapy for unresectable liver cancer.
• Group 2B
• a. Patients currently receiving, planning to receive, or recently completed definitive IMRT for unresectable liver cancer.
• Group 3
• a. Healthy age- and gender- matched individuals
• All Groups
• Patients of all genders, races and nationalities will be solicited.
• Age >18 years
• Ability to understand and the willingness to sign a written informed consent document.

You may not qualify if…

• Patients with compromised immunologic responses due to an uncontrolled intercurrent immunodeficiency (e.g., Human immunodeficiency virus (HIV), X-linked agammaglobulinemia) or previous or current immune suppressive therapy
• a. Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial.
• Patients receiving intravenous immunoglobulin (IVIG) during the study or in the three months prior to study enrollment.
• Patients with psychiatric illness/social situations that would limit compliance with study requirements.
• Individuals with previous pneumococcal vaccination in the last 5 years.
• Individuals with severe allergy to any of the vaccine components

Where it is running

• MD Anderson Cancer Center — Houston, Texas, United States (enrolling)

Full record on ClinicalTrials.gov

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