Effect of Sleep Extension on Ceramides in People With Overweight and Obesity

Recruiting now · Not applicable

Conditions studied: Lifestyle Factors, Overweight and Obesity, Insulin Sensitivity, Eating Habit, Sleep Hygiene, Type 2 Diabetes, Sleep, Sleep Deprivation, Insufficient Sleep Syndrome

In brief

The overall goal is to determine how a sleep extension intervention (increasing time in bed) in individuals who maintain less than 6.5 hours sleep per night affects their plasma ceramides and insulin sensitivity. Participants will undergo a randomized controlled trial, with sleep extension (intervention) and healthy lifestyle (control) groups. The sleep extension is designed to increase participant's time in bed by 2 hours per night. Alternatively, the control group will receive basic health information (e.g., physical activity, goal setting, and nutrition when eating out).

Key facts

Study ID

NCT06180837

Run by

University of Utah

People needed

70

Starts

2024-02-12

Expected to finish

2028-05-01

Last updated by the study team

2026-08-05

Who can join

Age: 18 and older, up to 45. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age: 18-45 years old; equal numbers of men and women
• Body mass index (BMI): 27.5-34.9 kg/m2
• Sleep Habits: habitual self-reported average total sleep time (TST) <6.5 hours per night for prior 6 months

You may not qualify if…

• Clinically diagnosed sleep disorder or major psychiatric illness
• Evidence of significant organ dysfunction or disease (e.g., heart disease, kidney disease)
• Clinically diagnosed diabetes or fasting plasma glucose ≥126 mg/dL or HbA1c ≥6.5%
• Use of prescription drugs or substances known to influence sleep or glucose metabolism, or anticoagulant medications.
• Cancer that has been in remission less than 5 years
• Pregnant/nursing, experiencing menopause or post-menopausal
• Shift-work: current or history of within last year
• Weight change: >10% of body weight over prior six months
• Current enrollment in weight loss or physical activity program like the Diabetes Prevention Program
• Currently smoking
• Alcohol intake>14 drinks per week or >3 drinks per day

Where it is running

• College of Health Research Complex--University of Utah — Salt Lake City, Utah, United States (enrolling)

Full record on ClinicalTrials.gov

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