Homburg Renal Evaluation Study on the Clinical Utility of Early AKI Diagnosis

Recruiting now

Conditions studied: Acute Kidney Injury

In brief

Critically ill patients are at risk of developing a sudden decrease of kidney function which may be detected by a decrease in urine output or is diagnosed on the basis of blood tests for substances normally eliminated by the kidney, primarily creatinine. Because it takes about 24 hours for the creatinine level to rise, even if both kidneys have ceased to function, better markers are needed. This trial is investigating if the marker urinary dickkopf-3 (uDKK3) allows an early prediction of a sudden decrease of kidney function.

Key facts

Study ID

NCT06180551

Run by

Universität des Saarlandes

People needed

1000

Starts

2023-12-01

Expected to finish

2027-06-01

Last updated by the study team

2023-12-22

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients treated on the intensive care units of Saarland University Hospital.

You may not qualify if…

• Patients on renal replacement treatment before admission to the intensive care unit.
• Patients with chronic kidney disease stage CKD G3b or below.
• Known kidney disease.
• Kidney transplantation.
• Intoxications leading to dialysis treatment.
• Participation in other clinical trials.

Where it is running

• Universitätsklinikum des Saarlandes — Homburg, Saarland, Germany (enrolling)

Full record on ClinicalTrials.gov

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