Chronic Remote Ischemic Conditioning in Vascular Cognitive Impairment: A Dose Escalation Study

Status unconfirmed · Not applicable · Has a placebo group

Conditions studied: Age-related Cerebral White Matter Changes, Cognition Disorder

In brief

To evaluate the dose-response of relevant blood biomarkers to remote ischemic conditioning in patients with age-related cerebral white matter hyperintensities on MRI, in preparation for a subsequent larger efficacy trial.

Key facts

Study ID

NCT06179797

Run by

Augusta University

People needed

40

Starts

2020-08-15

Expected to finish

2023-12-15

Last updated by the study team

2023-12-22

Who can join

Age: 56 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥55 years
• Head MRI in the past 6 months showing no more than moderate age related cerebral white matter changes (Fazekas score 0-2).
• Able to walk without assistance \& independently perform basic activities of daily living.
• Able to understand this study and agree for a valid consent.

You may not qualify if…

• Prior non-lacunar (cortical) stroke. 2. Unable to cooperate with the use of the conditioning device. 3. Confounding illness that might interfere with the interpretation of results (such as active malignancy or multiple sclerosis).
• Contraindication to transient arm ischemia in either arm (such as symptomatic peripheral artery disease).

Where it is running

• Wellstar MCG Health — Augusta, Georgia, United States (enrolling)

Full record on ClinicalTrials.gov

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