Effect of Ketamine and Etomidate During RSI on Long Term Outcomes
Enrolling by invitation
Conditions studied: Post-Traumatic Stress Disorder, Acute Respiratory Failure
In brief
The RSI-LTO study collects long-term outcomes from the RSI trial (NCT05277896). One-third of adults who are intubated in the ED or ICU experience symptoms of posttraumatic stress disorder (PTSD). PTSD is a psychiatric disorder triggered by a "shocking, scary, or dangerous event." Critical illness, tracheal intubation, and mechanical ventilation can be traumatic and distressing events. Patients may recall the intubation procedure, the feeling of the breathing tube in their throat, or being unable to move ("paralyzed"). While on the breathing machine, patients may experience delirium, frightening hallucinations, and delusions. Patients with PTSD after critical illness can be hypervigilant, anxious, and troubled by intrusive thoughts, nightmares, and flashbacks that last months to years after critical illness and that PTSD negatively impacts patients' marriages, work, and quality of life and increases patients' risk of depression, anxiety, substance use disorder, and suicide. Ketamine may prevent PTSD symptoms by blocking the pathways in the brain's glutaminergic system that are responsible for the formation of traumatic memories In outpatients with chronic PTSD, a single dose of ketamine has been shown to reduce PTSD symptoms for up to 2 weeks. Even a modest reduction in PTSD would translate into tens of thousands of fewer cases of PTSD each year, more cases of PTSD each year than any other medical intervention evaluated to date.
Key facts
- Study ID
- NCT06179485
- Run by
- Vanderbilt University Medical Center
- People needed
- 1756
- Starts
- 2022-04-06
- Expected to finish
- 2028-03-01
- Last updated by the study team
- 2026-06-02
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Enrolled in RSI trial (NCT05277896)
You may not qualify if…
- Aphasic or non-verbal prior to tracheal intubation
- Cannot follow commands prior to tracheal intubation
- Non-English speaking
- Deaf
Where it is running
- University of Alabama Hospital — Birmingham, Alabama, United States
- University of Colorado Denver — Aurora, Colorado, United States
- Denver Health Medical Center — Denver, Colorado, United States
- Hennepin County Medical Center — Minneapolis, Minnesota, United States
- Wake Forest Baptist Medical Center — Winston-Salem, North Carolina, United States
- Vanderbilt University Medical Center — Nashville, Tennessee, United States
Full record on ClinicalTrials.gov
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