One-year Patency Comparison Between Radial Artery and No-touch Saphenous Vein Grafts in Women Undergoing Isolated CABG

Recruiting now · Not applicable

Conditions studied: Cardiac Disease, Surgery-Complications, Graft Failure

In brief

The use of a graft from the left internal thoracic artery to the left anterior descending artery has become the gold standard for the indication of coronary artery bypass grafting. However, choosing a graft for the second-best coronary artery, focusing on long-term patency, is still a challenge. The saphenous vein using the "no-touch" technique is an alternative to a radial artery graft, but there is little evidence, especially in women. This randomized clinical study aims to compare the patency of these grafts in the second-best coronary artery in women undergoing coronary artery bypass grafting.

Key facts

Study ID

NCT06179329

Run by

University of Sao Paulo General Hospital

People needed

150

Starts

2024-01-01

Expected to finish

2027-12-30

Last updated by the study team

2025-12-12

Who can join

Age: 18 and older, up to 75. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Women aged 18 years or older and younger than 75 years, undergoing isolated and primary myocardial revascularization surgery, with triarterial coronary artery disease (three vessels involved) in vessels subject to surgical revascularization and left ventricular ejection fraction greater than 35%. The target coronary vessels of the study will be those in the territory of the left circumflex artery and the right coronary artery, which must have at least 1.5 mm in diameter, and with proximal obstructive lesions of at least 70%.

You may not qualify if…

• Preoperative conditions:
• Lack of the patient's written informed consent.
• Presence of poorly controlled diabetes, with a glycated hemoglobin value >8 mg/dl.
• Emergency or salvage surgery, where the intervention needs to be performed quickly due to the critical clinical condition of the patient.
• Renal failure with glomerular filtration rate (creatinine clearance) <30 mL/min.
• Inability to use the saphenous and/or radial vein
• Positive Allen test using a pulse oximeter
• Presence of abnormal flow detected by means of a Doppler exam in one of the grafts to be used.
• History of vasculitis or Raynaud's syndrome, varicose veins, or history of previous saphenous vein removal
• Conditions that may affect patient follow-up
• Presence of advanced peripheral arterial disease
• Known contrast allergy: Presence of a documented allergy to the contrast agent used in radiological procedures.
• Impossibility of tracking due to geographic inaccessibility.
• Patients with lack of adherence to guidelines and/or prescribed medications.

Where it is running

• Instituto do Coração do Hospital das Clínicas da Faculdade de Medicina de São Paulo — São Paulo, São Paulo, Brazil (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.