Transcranial Pulse Stimulation (TPS) in Post-COVID-19

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Post-COVID-19 Syndrome, Fatigue

In brief

The objective of the present study is to demonstrate treatment efficacy of transcranial pulse stimulation for patients with Post-COVID-19 related neurological symptoms (fatigue, cognitive deficits, mood deterioration). Fatigue, as measured by the Fatigue Impact Scale (FIS), will represent the primary outcome variable. The verum treatment will be compared to a sham (placebo) condition.

Key facts

Study ID

NCT06178952

Run by

Medical University of Vienna

People needed

102

Starts

2024-01-08

Expected to finish

2027-01-01

Last updated by the study team

2025-12-23

Who can join

Age: 20 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Signed written informed consent
• PCR-confirmed SARS-CoV-2 infection, laboratory confirmed antibody detection for SARS-CoV-2, or physician-verified COVID-19 infection
• At least 12 months after initial SARS-CoV-2 infection that led to Post-COVID (subsequent SARS-CoV-2 infections are not a reason for exclusion)
• Diagnosis of Post-COVID Syndrome or independent suspected diagnosis of Post-COVID Syndrome (Considering that physicians generally hesitate to provide clear-cut Post-COVID diagnoses, a tentative diagnosis by an independent general practitioner or a specialist in a field associated with Post-COVID will suffice for entering this study)
• Age: 20-80
• Evidence of a negative pregnancy test if medically adequate

You may not qualify if…

• Clinically relevant realization of pre-COVID diseases with similar symptoms as Post-COVID
• MoCA score <17 (cut-off for dementia)
• BDI-II score ≥29 (cut-off for severe depression)
• FIS <10 (cut-off for no fatigue)
• Brain implants
• Non-MR-compatible metal parts in the body
• Metal parts in the head
• Use of anticoagulants
• Non-MR-compatible claustrophobia
• Non-MR-compatible pacemaker
• Pregnant and breastfeeding women
• Clinically relevant history of surgery on the head, heart, or vessels
• Relevant corticosteroid treatments administered within 6 weeks prior to the first application
• Tumor of the head if relevant for treatment
• Blood clotting disorders
• Participation in other studies

Where it is running

• Medical University of Vienna — Vienna, State of Vienna, Austria (enrolling)

Full record on ClinicalTrials.gov

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