Towards Novel BIOmarkers to Diagnose SEPsis on the Emergency Room

Recruiting now

Conditions studied: Sepsis, Septic Shock, Sepsis, Severe, Infections, Infection Viral, Infection, Bacterial, Infections, Respiratory

In brief

Objectives: 1. To compare the immune response of patients with or without sepsis presenting to the ED with a(n) (suspected) infection. 2. To determine immune response aberrations that are associated with an increased risk of developing sepsis in patients presenting to the ED with a(n) (suspected) infection without sepsis. 3. To determine the long term cognitive and physical sequelae of sepsis after admission.

Key facts

Study ID

NCT06178822

Run by

Amsterdam University Medical Centers (UMC), Location Academic Medical Center (AMC)

People needed

3300

Starts

2022-10-25

Expected to finish

2026-10-01

Last updated by the study team

2025-10-02

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18 years or higher
• Presentation at the Emergency Department (ED)
• Clinical suspicion of infection or earlier confirmed infection
• Modified Early Warning Score (MEWS) of 2 or higher

You may not qualify if…

• No informed consent given

Where it is running

• Amsterdam UMC, location VUMC — Amsterdam, North Holland, Netherlands (enrolling)
• Amsterdam UMC, location AMC — Amsterdam, North Holland, Netherlands (enrolling)
• Flevoziekenhuis — Almere Stad, Flevoland, Netherlands

Full record on ClinicalTrials.gov

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