Evaluation of Efficacy and Safety of VX-548 for Painful Lumbosacral Radiculopathy (PLSR)

Completed · Phase 2 · Has a placebo group

Conditions studied: Painful Lumbosacral Radiculopathy

In brief

The purpose of the study is to evaluate the efficacy and safety of VX-548 in treating participants with PLSR.

Key facts

Study ID

NCT06176196

Run by

Vertex Pharmaceuticals Incorporated

People needed

218

Starts

2023-12-13

Expected to finish

2024-10-16

Last updated by the study team

2025-10-01

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Arizona Research Center — Phoenix, Arizona, United States
• Trovare Clinical Research — Bakersfield, California, United States
• Velocity Clinical Research - Banning — Banning, California, United States
• Velocity Clinical Research - San Diego — La Mesa, California, United States
• Probe Clinical Research — Riverside, California, United States
• Pain Management and Injury Relief — Thousand Oaks, California, United States
• Visionary Investigators Network — Aventura, Florida, United States
• Nature Coast Clinical Research - Crystal River — Crystal River, Florida, United States
• JY Research Institute — Cutler Bay, Florida, United States
• Fleming Island Center for Clinical Research — Fleming Island, Florida, United States
• Convenient Medical Research — Hialeah, Florida, United States
• Jacksonville Center for Clinical Research — Jacksonville, Florida, United States
• L&C Professional Medical Research Institute — Miami, Florida, United States
• Medical Research of Westchester — Miami, Florida, United States
• ARSN-Brain and Spine Institute — Port Orange, Florida, United States
• Accel Research Site - St. Petersburg/Largo — Seminole, Florida, United States
• Atlanta Center for Medical Research — Atlanta, Georgia, United States
• ClinCept Clinical Research — Columbus, Georgia, United States
• Accel Research Sites - Neurostudies — Decatur, Georgia, United States
• Velocity Clinical Research - Savannah Neurology Specialists — Savannah, Georgia, United States
• Velocity Clinical Research - Savannah — Savannah, Georgia, United States
• Center for Pain Management and Rehab — Stockbridge, Georgia, United States
• Velocity Clinical Research - Boise — Meridian, Idaho, United States
• Healthcare Research Network II, LLC — Flossmoor, Illinois, United States
• Hope Research Institute — Phoenix, Arizona, United States

Full record on ClinicalTrials.gov

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