PPOS (Progestin Primed Ovarian Stimulation) and Corifollitropin Alfa (CFA) Cross-over Study
Recruiting now · Phase 4
Conditions studied: Ovarian Stimulation, Quality of Life, Preimplantation Genetic Testing, Fertility Preservation
In brief
P-CCROSS is a randomized, prospective monocentric phase 4 study with a crossover study design. The aim of the study is to compare patient satisfaction (by means of questionnaires) and treatment compliance with IVF treatment with CFA (corifollitropin alfa) and PPOS (Progestin-Primed Ovarian Stimulation) versus conventional IVF treatment with a recombinant FSH/GnRH antagonist. The study will also compare patients undergoing elective fertility preservation versus PGT-A (pre-implantation genetic testing for aneuploidy) patients.The study will have a crossover design so that patients will receive both forms of treatment. The investigators will also compare the endocrine profile and ovarian response of CFA/PPOS versus rFSH/GnRH ovarian stimulation cycles.
Key facts
- Study ID
- NCT06175832
- Run by
- University Hospital, Ghent
- People needed
- 60
- Starts
- 2025-01-27
- Expected to finish
- 2027-12-31
- Last updated by the study team
- 2025-12-26
Who can join
Age: 18 and older, up to 40. Sex: female. Healthy volunteers: not accepted.
You may not qualify if…
- contra-indication for ovarian stimulation
- expected poor ovarian response (Bologna Criteria)
- PCOS patients
- refusal to fill out questionnaires before, during and after treatment
- simultaneous participation in another clinical study
- untreated and uncontrolled thyroid dysfunction;
- current use of oral contraceptives, anti-psychotics, anti-epileptics or chemotherapy;
- pregnant or breastfeeding women. A woman is considered of childbearing potential (WOCBP), i.e. fertile, following menarche and until becoming postmenopausal unless permanently sterile. Permanent sterilization methods include hysterectomy, bilateral salpingectomy and bilateral oophorectomy. A postmenopausal state is defined as no menses for 12 months without an alternative medical cause.
Where it is running
- University Hospital Ghent — Ghent, Belgium (enrolling)
Full record on ClinicalTrials.gov
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