Study of Vudalimab or Pembrolizumab in Combination With Chemotherapy as First-line Treatment in Patients With Advanced NSCLC
Stopped early · Phase 1/Phase 2
Conditions studied: Nonsquamous Non-small Cell Lung Cancer
In brief
The purpose of this study is to identify the recommended dose of vudalimab to be used in combination with chemotherapy (Part 1) and to evaluate the efficacy and safety of vudalimab plus standard of care chemotherapy relative to pembrolizumab plus chemotherapy (Part 2) as first-line treatment in patients with nonsquamous non-small cell lung cancer (NSCLC).
Key facts
- Study ID
- NCT06173505
- Run by
- Xencor, Inc.
- People needed
- 28
- Starts
- 2023-12-27
- Expected to finish
- 2025-12-29
- Last updated by the study team
- 2026-03-13
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Palo Verde Cancer Specialists — Glendale, Arizona, United States
- Eastern Connecticut Hematology and Oncology Associates — Norwich, Connecticut, United States
- Hematology Associates of Fredericksburg — Fredericksburg, Virginia, United States
- Jessa Ziekenhuis - Campus Virga Jesse — Hasselt, Belgium
- St. Lukes (Agios Loucas) Hospital — Thessaloniki, Greece
- Hospital Sultan Ismail — Johor Bahru, Malaysia
- Hospital Umum Sarawak — Kuching, Malaysia
- Institut Kanser Negara — Putrajaya, Malaysia
- The Netherlands Cancer Institute - Antoni van Leeuwenhoek — Amsterdam, North Holland, Netherlands
- ULS do Alto Ave, EPE - Hospital da Senhora da Oliveira Guimarães — Guimarães, Portugal
- NEXT Oncology-Hospital Quirónsalud Barcelona — Barcelona, Spain
- Hospital Clinic i Provincial de Barcelona — Barcelona, Spain
- Institut Català d'Oncolgia de Girona — Girona, Spain
- Hospital Clínico San Carlos — Madrid, Spain
- Hospital Universitario La Paz — Madrid, Spain
- Changhua Christian Hospital — Changhua, Taiwan
- Kaohsiung Medical University Chung-Ho Memorial Hospital — Kaohsiung City, Taiwan
Full record on ClinicalTrials.gov
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