FET PET in Differentiating Tumour Progression From Pseudoprogression in High Grade Glioma
Recruiting now · Phase 2
Conditions studied: Glioma, Malignant
In brief
The goal of this clinical trial is to evaluate the performance characteristics of O-(2-\[18F\]fluoroethyl)-L-tyrosine (FET) PET in differentiating pseudoprogression from tumour progression in patients with equivocal conventional imaging and determine the sensitivity and specificity of \[18F\]FET-PET in delineating disease. The main question\[s\] it aims to answer are: * whether 18F-FET-PET will demonstrate high diagnostic accuracy to detect true tumour progression * whether we can optimise the threshold cut-offs for TBRmax and other relevant parameters in discriminating pseudoprogression and disease progression Participants will undergo a limited 18F-FET PET/CT of the brain in SGH.
Key facts
- Study ID
- NCT06172595
- Run by
- Singapore General Hospital
- People needed
- 22
- Starts
- 2023-12-21
- Expected to finish
- 2026-02-28
- Last updated by the study team
- 2024-12-03
Who can join
Age: 21 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Men or Women, aged 21 years or older at time of screening
- Histologically confirmed diagnosis of malignant glioma (defined as WHO grade III or IV) with previous RT to tumour
- With enlarging contrast-enhancing and/or T2W/FLAIR-hyperintense lesion(s) on MRI within the previous RT field
- Gliomas with Isocitrate dehydrogenase (IDH) wild-type status, as defined on immunohistochemistry
- Subject must consent to undergo all study procedures
You may not qualify if…
- Low-grade gliomas (histology grade 1 or 2 by WHO classification)16,17
- Previous bevacizumab or other vascular endothelial growth factor (VEGF) targeting agents or anti-angiogenic treatments.
- Proven cerebral metastases
- IDH-mutated gliomas
- Pregnancy/ breast-feeding
Where it is running
- National Cancer Centre Singapore — Singapore, Singapore (enrolling)
- Singapore General Hospital — Singapore, Singapore (enrolling)
Full record on ClinicalTrials.gov
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