Effect of Nitrate Supplementation on Blood Pressure and Microvascular Function of Resistant Hypertensive Patients

Recruiting now · Early Phase 1 · Has a placebo group

Conditions studied: Arterial Hypertension, Resistant Hypertension, Microvascular Function, Nitrate Supplementation

In brief

Arterial hypertension (AH) has been identified as an important public health problem and considered a new epidemic with high mortality and morbidity. High blood pressure (BP) levels increase the chances of coronary artery disease (CAD), heart failure (HF), stroke, chronic renal failure (CRF) and death. Beetroot powder may be an easier way to increase the availability of nitric oxide and consequently vasodilation in these patients. However, studies are needed to evaluate its benefits in patients with AH.

Key facts

Study ID

NCT06169241

Run by

National Institute of Cardiology, Laranjeiras, Brazil

People needed

50

Starts

2023-11-01

Expected to finish

2026-12-01

Last updated by the study team

2026-04-13

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Resistant hypertension, with a diagnosis described in the medical record, without changing medications or increasing doses in the last 30 days.

You may not qualify if…

• neoplasms
• heart failure
• use of medications with nitrate in their formula
• patients undergoing renal denervation

Where it is running

• National Institute of Cardiology — Rio de Janeiro, Brazil (enrolling)

Full record on ClinicalTrials.gov

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