A Study of Glipizide to Treat High Blood Sugar in People With Pancreatic Cancer
Running, not enrolling · Phase 2
Conditions studied: Pancreatic Cancer, Pancreatic Carcinoma, Pancreatic Ductal Adenocarcinoma, Pancreatic Cancer Metastatic, Metastatic Pancreatic Cancer, Metastatic Pancreatic Ductal Adenocarcinoma
In brief
The purpose of this study is to find out how effective and safe glipizide is for lowering blood sugar in people with pancreatic cancer.
Key facts
- Study ID
- NCT06168812
- Run by
- Memorial Sloan Kettering Cancer Center
- People needed
- 29
- Starts
- 2023-12-05
- Expected to finish
- 2026-12-05
- Last updated by the study team
- 2026-08-06
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Cohort 1
- Age ≥18 years
- Biopsy-proven PDAC
- Radiological evidence and clinical assessment that patient has active disease (local, locally advanced, or metastatic)
- Willing and able to comply with the requirements of the protocol
- Willing to use their bluetooth-enabled wifi or cellular mobile device
- Hemoglobin A1c (HbA1c) > 7%, or fructosamine > 287 mg/dL, or random glucose > 180 mg/dL, or strong clinical suspicion that patient has hyperglycemia, making it reasonable to expect their mean daily glucose is ≥154 mg/dL
- Eastern Cooperative Oncology Group performance status ≤2
- BMI \<30 kg/m2
- Cohort 2a
- Age ≥18 years
- Biopsy-proven PDAC
- Radiological evidence and clinical assessment that patient has active disease (local, locally advanced, or metastatic pancreatic cancer)
- Clinical diagnosis of diabetes mellitus
- Active care at MSK (defined as at least 1 physician or APP encounter every 3 months) for PDAC during the period from which data were recorded in the electronic medical record (in this retrospective study patients need not be under active care at the time the research is conducted)
- At least 1 electronic prescription for a sulfonylurea (glipizide, glimepiride, or glyburide) or metformin
- Three-month baseline period before metformin or sulfonylurea initiation in which the participant does not receive either drug class or insulin
- Body weight recorded within 3 months before start of metformin or a sulfonylurea
- Cohort 2b
- Age ≥18 years
- Biopsy-proven PDAC
- Radiological evidence and clinical assessment that patient has active disease (local, locally advanced, or metastatic)
- Active care at MSK (defined as at least 1 physician or APP encounter every 3 months) for PDAC during the period of data collection
- Apparent current use based on chart review of metformin (but not sulfonylurea); sulfonylurea (but not metformin); or neither drug
You may not qualify if…
- Cohort 1
- Use during the past month of any antidiabetic medication other than metformin at home (sporadic use [fewer than 1 of 7 days during the past month] is permitted)
- Changes in metformin dose in the past month
- History of sulfonylurea intolerance or allergy
- History of severe hypoglycemia (hypoglycemia requiring emergency medical assistance, emergency room or urgent care visit, or hospital admission)
- AST or ALT \>3 x upper limit of normal
- Glomerular filtration rate \<30 mL/min/1.73m2
- Daily chronic use of any dose of corticosteroids (as distinct from intermittent exposure to steroids as part of cyclic chemotherapy)
- Inability to wear CGM
- Cohort 2a
- Greater than trace ascites documented on imaging or physical exam
- Cohort 2b
- Greater than trace ascites documented on imaging or physical exam
Where it is running
- Memorial Sloan Kettering at Basking Ridge (Limited Protocol Activities) — Basking Ridge, New Jersey, United States
- Memorial Sloan Kettering Monmouth (Limited protocol activities) — Middletown, New Jersey, United States
- Memorial Sloan Kettering Bergen (Limited Protocol Activities) — Montvale, New Jersey, United States
- Memorial Sloan Kettering Cancer Center @ Suffolk-Commack (Limited protocol activities) — Commack, New York, United States
- Memorial Sloan Kettering Westchester (Limited Protocol Activities) — Harrison, New York, United States
- Memorial Sloan Kettering Cancer Center — New York, New York, United States
- Memorial Sloan Kettering Nassau (Limited Protocol Activities) — Uniondale, New York, United States
Full record on ClinicalTrials.gov
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