Pharmacokinetics and Pharmacodynamics of Subcutaneous vs Intravenous Furosemide in Healthy Volunteers

Completed · Phase 1

Conditions studied: Heart Failure, Fluid Overload

In brief

This study aims to compare the pharmacokinetics and pharmacodynamics of subcutaneous (SC) and intravenous (IV) furosemide. The test formulation in this study is furosemide injection, 80 mg/1 mL, buffered to a neutral pH for SC administration via an autoinjector. A commercial formulation of furosemide injection, USP, solution 10 mg/mL administered as a 40 mg IV injection over 2 minutes followed by a second dose of 40 mg, 2 hours later, will serve as the reference drug. The objectives of this study are: * To estimate the bioavailability and describe the pharmacokinetics and pharmacodynamics of furosemide administered as SC injection via autoinjector compared with equivalent dose of furosemide administered as two 40 mg IV injections, two hours apart. * To describe the safety and tolerability of furosemide administered as SC injection via an autoinjector.

Key facts

Study ID

NCT06167707

Run by

scPharmaceuticals, Inc.

People needed

21

Starts

2024-04-19

Expected to finish

2024-06-14

Last updated by the study team

2026-03-30

Who can join

Age: 45 and older, up to 80. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• An Institutional Review Board (IRB) approved informed consent is signed and dated prior to any study-related activities.
• Male and female subjects 45 to 80 years of age.
• Has the ability to understand the requirements of the study and is willing to comply with all study procedures.
• In the opinion of the Investigator, able to participate in the study.

You may not qualify if…

• Pregnant or lactating women or women of childbearing age who are not willing to use an adequate form of contraception.
• Systolic BP (SBP) < 90 mmHg at screening or baseline.
• Heart rate > 110 beats per minute (BPM) at screening or baseline.
• Temperature > 38°C (oral or equivalent).
• Serum potassium < 3.0 or > 5.5 mEq/L at screening.
• Other significant cardiac abnormalities which may interfere with study participation or study assessments.
• Current or planned treatment during the study with any IV therapies, including inotropic agents, vasopressors, levosimendan, nesiritide or analogues. scPharmaceuticals, Inc. SCP-111 PK/PD Study Protocol Number: scP-04-001 Confidential Page 14 of 56
• Presence of implanted ventricular assist device, cardiac defibrillator or pacemaker.
• Severely impaired renal function, defined as an estimated glomerular filtration rate (eGFR) at screening admission < 30 mL/min/1.73m2, calculated using the simplified Modification of Diet in Renal Disease (sMDRD) equation.
• Urinary retention due to bladder emptying disorders and/or urethral narrowing.
• Presence or need for urinary catheterization.
• Reported history of hepatic cirrhosis.
• Administration of intravenous radiographic contrast agent within 72 hours prior to Screening.
• Concomitant or any use within past 30 days of drugs known to interact with furosemide (aminoglycoside antibiotics, ethacrynic acid, high doses of salicylates, cisplatin, tubocurarine, succinylcholine, chloral hydrate, phenytoin, methotrexate, indomethacin, or lithium).
• Administration of an investigational drug or implantation of investigational device, or participation in another interventional clinical trial, within 30 days prior to Screening.
• Any surgical or medical condition which in the opinion of the investigator may interfere with participation in the study or which may affect the outcome of the study.
• Positive urine drug screen at Screening or Baseline.
• Blood alcohol concentration > 2 mg/dL (0.02%) at Screening.
• Alcohol breath test > 2 mg/dL (0.02%) on admission to the CRU.
• History of severe allergic or hypersensitivity reactions to furosemide or any component of the SCP-111 formulation (tromethamine or benzyl alcohol)

Where it is running

• Elixia EPCT, LLC — Tampa, Florida, United States

Full record on ClinicalTrials.gov

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