NBI Combined With MRI to Guide CTV Optimization in Eccentric Nasopharyngeal Carcinoma
Recruiting now · Not applicable
Conditions studied: Nasopharyngeal Carcinoma by AJCC V8 Stage
In brief
This is a prospective, single-center clinical trial in eccentric nasopharyngeal carcinoma (NPC) patients. The aim of this study is to evaluate the efficacy and safety of NBI combined with MRI-guided optimized CTV compared with conventional CTV, and to compare the radiotherapy-related adverse events and quality of life between the two groups.
Key facts
- Study ID
- NCT06167109
- Run by
- Chongqing University Cancer Hospital
- People needed
- 60
- Starts
- 2023-10-20
- Expected to finish
- 2026-10-01
- Last updated by the study team
- 2023-12-12
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Males and females ≥18 years of age;
- ECOG Performance Status 0,1 or 2;
- Pathologically diagnosed as nasopharyngeal carcinoma;
- Pretreatment nasopharynx and neck MRI imaging;
- Nasopharyngeal suspected lesions were examined by NBI endoscopy;
- Meeting the definition of eccentric NPC with ipsilateral (affected side) staging of T1-4 and contralateral (healthy side) staging of T0;
- Patients evaluated without contraindications to radiotherapy;
- Voluntary participation in clinical research, and signed informed consent.
You may not qualify if…
- Patients who did not successfully undergo all three examinations (MRI, NBI, and endoscopic biopsy);
- Other rare pathological types, such as adenocarcinoma;
- Patients with tumor invasion of the clivus;
- Patients whose contralateral retropharyngeal lymph nodes met the diagnostic criteria;
- Invasion of paranasal sinuses (except simple sphenoid invasion).
Where it is running
- Chongqing University Cancer Hospital — Chongqing, Chongqing Municipality, China (enrolling)
Full record on ClinicalTrials.gov
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