Dose-Response Effect Exercise and Depression

Completed · Not applicable

Conditions studied: Depression

In brief

The present study aims to address gaps in the literature by evaluating the objectively measured dose-response relationship between exercise and depression symptoms; examining changes in resting (Brain-derived Neurotrophic Factor) BDNF from baseline to week 10 of an exercise intervention; and assessing varying exercise intensities on enjoyment, affect, and health-related quality of life in sedentary young adult college students.

Key facts

Study ID

NCT06166095

Run by

University of Central Florida

People needed

48

Starts

2023-07-01

Expected to finish

2024-12-01

Last updated by the study team

2025-03-27

Who can join

Age: 18 and older, up to 25. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• enrolled UCF college students aged 18 to 25
• mild to moderate depressive symptoms
• willing to wear a Fitbit for extended periods of time during the study
• willing to participate in moderate-to-vigorous PA
• physically able to participate in exercise safely

You may not qualify if…

• under 110 lbs
• history of bad reaction to a past blood draw
• have been advised by a medical provider to not give/donate blood
• presence of anemia
• current cognitive therapy or antidepressant medication
• diagnosis of a co-occurring condition such as attention deficit hyperactivity disorder (ADHD)
• diagnosis of a serious mental illness (SMI) such as schizophrenia or bipolar disorder
• pregnant or nursing
• current smoker
• beta-blocker medications

Where it is running

• University of Central Florida — Orlando, Florida, United States

Full record on ClinicalTrials.gov

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