Liposomal and Standard Bupivacaine in Thoracic Paravertebral Block for Post-Thoracoscopic Pain
Recruiting now · Phase 4
Conditions studied: Thoracic Paravertebral Block, Postoperative Analgesia, Thoracoscopic Lobectomy
In brief
I. Research purpose 1.1 Main Objective: To investigate the efficacy and safety of bupivacaine liposome thoracic paravertebral nerve block for postoperative analgesia after thoracoscopic lobectomy 1.2 Exploratory Objective: To investigate the noninferiority of bupivacaine liposomes in thoracic paravertebral nerve block with standard bupivacaine
Key facts
- Study ID
- NCT06165991
- Run by
- Yongtao Sun
- People needed
- 496
- Starts
- 2024-06-01
- Expected to finish
- 2026-01-31
- Last updated by the study team
- 2026-01-09
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- 1) Age ≥18 years old;
- Patients undergoing unilateral initial thoracoscopic lobectomy under general anesthesia (TV or robot-assisted);
- American Society of Anesthesiologists (ASA) Grade I - III;
- Voluntarily participate in the study and sign the informed consent.
You may not qualify if…
- 1) Pregnant or lactating women;
- Pulmonary wedge-shaped resection;
- ≥2 thoracic drainage tubes;
- Abnormal liver function: ALT and/or AST>2×ULN, or
- TBIL≥1.5×ULN;
- Renal function impairment (serum creatinine >176μmol/L), or received dialysis treatment within 28 days before surgery;
- Participate in another research trial involving an investigational drug within 6 months;
- A history of drug or alcohol abuse;
- Long-term use of opioids (more than 3 months or more than 5 mg daily morphine equivalent per day for 1 month);
- History of allergy to local anesthetics or one of the investigational drugs;
- Uncontrolled mental or neurological symptoms.
Where it is running
- Qianfoshan Hospital, The First Hospital affiliated of Shandong First Medical University — Jinan, Shandong, China (enrolling)
Full record on ClinicalTrials.gov
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