Convergent Ablation Plus Left Atrial Appendage Isolation for the Treatment of Persistent Atrial Fibrillation

Recruiting now · Not applicable

Conditions studied: Persistent Atrial Fibrillation, Atrial Fibrillation, Persistent, Atrium; Fibrillation, Atrial Arrhythmia

In brief

A randomised controlled clinical trial to assess efficacy of convergent ablation with the LARIAT procedure, as compared to standard endocardial catheter ablation in patients with long-standing persistent atrial fibrillation (AF).

Key facts

Study ID

NCT06165510

Run by

Barts & The London NHS Trust

People needed

48

Starts

2024-08-02

Expected to finish

2026-11-01

Last updated by the study team

2026-06-25

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age > 18 years; < 80 years
• Persistent AF > 1-year duration
• Left atrium size < 6cm
• Pts should be able to provide written informed consent.

You may not qualify if…

• Subjects currently enrolled in another investigational study except in case of observational registry with no associated treatments.
• Subject has a reversible cause of AF or transient AF
• Subject is absent of LAA or if the LAA is previously surgically ligated
• Subject has had previous cardiac surgery or abdominal surgery.
• Subject has contraindication to anticoagulation.
• Patients with hypertrophic cardiomyopathy.
• Patients with significant valve disease.
• Subject has had previous catheter or surgical ablation

Where it is running

• St Bartholomew's Hospital — London, United Kingdom (enrolling)

Full record on ClinicalTrials.gov

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