18F-FAPI PET/MRI Imaging in Myelofibrosis: a Prospective Observational Study.
Recruiting now
Conditions studied: Myelofibrosis
In brief
This study intends to use a prospective, observational, self-controlled, multi-center study design to evaluate the feasibility and diagnostic efficacy of 18F-FDG PET/CT and 18F-FAPI PET/MRI imaging for the evaluation of systemic fibrosis in MF patients based on the results of bone marrow pathological biopsy, and to analyze the relationship between imaging results and clinical prognosis.
Key facts
- Study ID
- NCT06164561
- Run by
- First Affiliated Hospital of Zhejiang University
- People needed
- 57
- Starts
- 2023-11-21
- Expected to finish
- 2026-12-31
- Last updated by the study team
- 2026-02-04
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients with primary myelofibrosis or myelofibrosis secondary to myeloid tumors were diagnosed according to the diagnostic criteria of who 2022.
- Stable vital signs, ECOG score ≥ 2 points, tolerate and cooperate to complete 18F-FDG PET/CT and 18F-FAPI PET/MRI examination.
- The interval between imaging ,hematologic, cytogenetic and pathology was < 2 weeks.
- Willing to accept 18F-FDG PET/CT and 18F-FAPI PET/MRI , sign the informed consent.
You may not qualify if…
- Inability or unwillingness to provide informed consent.
- Other malignancies, autoimmune diseases, or chronic active infections were diagnosed within 1 year before the diagnosis of myelofibrosis.
- Current infection was present within 1 week before PET examination.
- Pregnant or lactation.
- Unable to follow protocol to complete follow-up.
- Have received glucocorticoid therapy within 2 weeks before PET imaging examination.
- Using granulocyte colony-stimulating factor (G-CSF) within 4 weeks prior to PET imaging.
Where it is running
- The First Affiliated Hospital, Zhejiang University School of Medicine — Hangzhou, Zhejiang, China (enrolling)
Full record on ClinicalTrials.gov
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